The main protein identified for the treatment of Alzheimer’s disease: Study

Using the human -induced pluripotent stem cell (IPSCs), the international team displayed that a specific version of Tau proteins, known as 1N4R isoform, mediate the harmful effects of protein clumping in human brain cells.

The study was led by Dr. Hans Zempel did it from the Institute of Human Genetics, who is also a group leader at the Career Advancement Program (CAP) at the Center for Molecular Medicine Cologh (CMMC) at the University of Molecular Medicine Colon (CMMC). Also read Alzheimer’s movements in men are different: Why is it here worse than you think

If a person suffers from Alzheimer’s disease, some proteins accumulate in brain cells, which create clumps that restrain normal cell functions or even cause cells to die.

Studies Conclusions:

Dr. Bucolz and Dr. Zampel’s team has used state-of-the-art techniques such as CRISPR/CAS9 gene editing and live-cell imaging using human-induced pluripotent stem cell (IPSCs), to display that 1N4R is responsible for pathological effects on the isophyorm cell. IPSCs are human stem cells that originate from other cells.

For example, skin cells can be re -obtained in IPSCs and then converted into brain cells (neurons). Researchers tested various forms of tau protein by expressing them especially in nerve cells. This allowed them to analyze how each protein affects the isoform cell.

The first author of the study, Dr. According to Sarah Buchalaz, “This study represents an important advance in helping us understand the mechanism of Alzheimer’s disease. 1n4R recognizes Tau as a major protein, we have discovered a possible new goal for future treatment.” Also read Alzheimer’s disease: Mystery solution of dead brain cells

The interdisciplinary approach of the study not only helps to better understand the Alzheimer’s disease, but also demonstrates the importance of human cell models in neurodynative research. The results of this study require further studies to translate into clinical applications, especially to validate the results in adequate animal models and to develop specific therapeutic medical intervention.

Note the readers: This article is only for informative purposes and is not an option for professional medical advice. Always consult your doctor with any question about a medical condition.