Elli Lily Weight Loss Drug: Ellie Lily has introduced a weekly injectable drug, Munjaro (tirizeptide) for obesity and type 2 diabetes in India after receiving approval from the Central Drugs Standard Control Organization (CDSCO). Targeting both Mounjaro GLP-1 and GIP receptors, it is notable for its dual-action mechanisms, which increases its effectiveness in blood sugar level management.
While ozmpic is often prescribed off-labeled for weight loss, Munjaro’s acceptance especially keeps it as a more targeted option for the management of obesity.
Let’s look closely how these two medicines compare in terms of efficacy, side effects and use.
What are Mounjaro and OzEmpic?
Ozmpic (semglutide) is a brand-nam injection pen used to treat type 2 diabetes. Meanwhile, Mounjaro (Tirzepatide) is a brand-name subcutaneous injection pen that is also used to treat type 2 diabetes.
- Mounjaro: Tirzepatide, a dual GLP-1 and GIP receptor agonist.
- Ozmpic: This includes semaglutide, a GLP -1 receptor agonist.
How do Mounjaro and OzEmpic work?
Mounjaro is not insulin, it is a type of drug that is called a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist.
Mounjaro is the first GIP/GLP-1 receptor agonist drug. This drug works by activating two receptors called GLP -1 and GIP, so that the levels of Incretins – hormones in the body can be increased.
It works by helping your body produce more insulin when needed. It also reduces the amount of glucose produced by the liver, or sugar, and slows down how quickly the food is digested. It all helps in reducing blood sugar levels and HBA1C.
Mounjaro increases how sensitive your body is to insulin. Mounjaro also indicates your pancreas that you make more insulin after eating, report Health line,
Meanwhile, the ozmpic perfectly targets the GLP -1 receptor to release insulin and slowly empty gastric, which promotes satiety and reduces blood sugar levels.
- Mounjaro: Aims both GLP-1 and GIP receptors to regulate blood sugar, promote insulin secretion and suppress hunger.
- OzEmpic: works by activating GLP-1 receptors, which helps to increase insulin production in response to food and low glucagon levels.
Weight Loss: Maunjaro vs. Ozampic
The clinical trial directly compared Munjaro to ozmpic when drugs are used for weight loss. Munjaro is not approved for use as a weight loss drug by Food and Drug Administration (FDA).
Both drugs can be prescribed off-labeled for weight loss, but are approved only for the treatment of type 2 diabetes.
The ozmpic is also approved to reduce the risk of severe cardiovascular problems.
In an American study of tirzepetides in participants with obesity, known as the Sarmount -1 clinical test, Maunjaro led the lowest dose (15mg) and average weight loss at the highest dose (15mg) and 15.4 kg at the lowest dose (5mg) in 72 weeks. Additionally, one of the three patients lost more than 25 percent of his body weight, much higher than 1.5 percent of the Placebo group.
Comment: The FDA has approved Maunjaro for the treatment of type 2 diabetes. In some cases, your doctor may prescribe Mounaro off-labeled for weight loss. Off-labeled drugs are used when the drug approved by an FDA is prescribed for a purpose, for which it is approved.
A notable study that used ozmpic (semglutide) for weight loss is phase 5 tests. The study consisted of adults who were overweight or thick and demonstrated the consequences of significant weight loss.
In the week 104, participants of the Semaglutide group reduced the average weight of 15.2 percent from baseline compared to a loss of 2.6 percent in the Placebo group. This resulted in a treatment difference of 12.6 percent marks, which highlights the efficacy of semaglutide for adequate and continuous weight loss.
Additionally, another cohort study mentioned in the National Library of Medicine has shown that patients treated with semaglutide lost 5.9 percent in 3 months and 10.9 percent in 6 months, and supported its effectiveness to reduce overweight.
Both Ozapic and Munjaro have warned. A boxing warning is the most serious warning from FDA.
Effectiveness: Maunjaro vs. Ozampic
In clinical trials, mounjaro (tirzepetide) has demonstrated better efficacy on ozmpic (semglutide) in the management of blood sugar levels, such as studies such as Phase 3 cross -2 tests show that Moonzaro has decreased by 2 percent to 2.3 percent compared to 1.9 percent compared to 1.9 percent.
Side Effects: Maunjaro vs. Ozmpic
According to medical websites such as Drug.com and The Czechup, common side effects of monjuro and ozmpic include similar gastrointestinal side effects, although frequency and severity may vary.
Here are the general side effects shared by both drugs:
| Mild side effects | Ozapic | Mounaro |
|---|---|---|
| Abdominal | , | |
| Abdominal pain | ||
| constipation | ||
| Diarrhea | ||
| Foolishing (gas) or buried | ||
| Indigestion | ||
| nausea and vomiting | ||
| loss of appetite | , | |
| Injection site reactions, such as troubles or malaise around the injection area |
Either patients need to consult the healthcare provider before taking the medicine. Both drugs take a boxing warning for potential thyroid cancer risks and should not be used by individuals with a history of Medulary Thyroid Carcinoma (MTC) or several endocrine neoplasia syndrome type 2 (male 2).
| Serious side effects | Ozapic | Mounaro |
|---|---|---|
| Diabetic retinopathy | , | |
| Serious digestive problems, dehydration and acute (sudden) renal injury | ||
| Acute gallbian disease | ||
| Hypoglycemia | ||
| Pancrexia | ||
| Risk of thyroid cancer* |
Costs and Availability: Mounjaro vs. ozepic
US Pharma Major Elli Lily on Thursday launched the much awaited diabetes and obesity management drug Munjaro (Tirzepetide) in India, priced 3,500 for 2.5 mg vial and 4,375 for 5 mg vial.
Meanwhile, the cost of an ozapic injection is the least 20,000 per shot if purchased from pharmacy, according to PrintIts weekly dose means that a customer can pay more than 80,000 per month.
Faqs about mounjaro and ozepic
What is the main difference between Mounjaro and OzEmpic?
The main difference between Mounjaro and OzEmpic lies in their active ingredients. Mounjaro contains tirzepatide, which targets both GLP-1 and GIP receptors, while ozempic has semaglutide, which only targets GLP-1 receptors.
Which medicine is more effective for weight loss?
Both drugs promote weight loss, but Maunjaro has shown a slightly overweight weight loss in clinical trials than ozapics.
Are there any serious side effects to be aware with silence or ozmpic?
Side effects of both ozapic and Munjaro such as nausea and gastrointestinal issues can occur. Mounjaro may be at greater risk of pancreatitis, while ozempic is at risk of thyroid tumors, although both risks are rare.
Is or vice versa better than ozmpic mounjaro?
Whether ozmpic or mounjaro is a better treatment option for you, which depends on many factors. Examples include how your body reacts to the drug, the condition that your doctor has given for treatment, and you have other health conditions.
To know if ozmpic or mounas can be a better treatment option, talk to your doctor.
(Please note: Mint does not support the drug for weight loss)
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