A study suggests that painful brain injury replaces small vessels in the brain, resulting in an accumulation of amyloid beta – a hallmark of Alzheimer’s disease. Conclusions suggest that vascular relaxation may be an initial driver in neurodynative disorders rather than due to neuronal damage. Also read Sweat brakes: Studies show that aerobic exercise reduces the risk of Alzheimer’s
A research team at the Strategic Research Area Multipark, Lund University argues that blood vessels in the brain keep the keys of future treatments. Brain trauma usually disrupts cerebral blood flow, possibly through pathological changes in vascular smooth muscle cells in the vascular wall.
Studies findings:
Lund University Professor Nicklas Markalund and Neurosurgeical Consultant at Skan University Hospital, looked deeply on molecular details with practical scientist Ilaknur Ogen.
In collaboration with the University of Upsala, he examined brain tissue from 15 patients, surgery removed due to their painful brain injuries within a week due to bleeding and inflammation.
They found that changes in vascular smooth muscle cells have been coincident with increased aggregation of amyloid-bita, a protein associated with Alzheimer’s disease. Also read Painful brain injury and relationship between heart disease: study
“We were surprised to see that even young patients demonstrated this accumulation of amyloid beta with vascular changes caused by brain trauma,” the first author of the study says Ilkur Ogen.
She continues: “Our findings suggest that vascular changes can be more important for neurodizonation from earlier views.”
Niclas Markland says: “This shows the existing paradigm in neurodizonation-related diseases that vascular relaxation can be an early phenomenon that triggers the progression of amyloid-related diseases rather than due to neuronal damage.”
While aging leads to functional changes in vascular, brain trauma can also increase and accelerate these processes in young patients.
Nevertheless, everyone affected by brain trauma develops Alzheimer’s disease. “We are not there yet, but hopefully, there will be an increase in knowledge about what happens in blood vessel cells after brain trauma, will open the possibilities for novel treatment,” Nicks is the conclusion of Markalund. . Also read The study explains how the immune system reacts differently to Alzheimer’s inflammation compared to regular infections
Note the readers: This article is only for informative purposes and is not an option for professional medical advice. Always consult your doctor with any question about a medical condition.
