Researchers at IIT Madras have patented an Indian spice-based nanomedicine for cancer treatment, aiming for market availability by 2028.
According to the researchers, these formulations showed anti-cancer activity against lung, breast, colon, cervical, oral and thyroid cell lines but were safe in normal cells.
Additionally, anti-cancer nanomedicines have been found to be safe in normal cells, he said.
“Although the therapeutic benefits of Indian spice oils have been known for centuries, their bioavailability has limited their application and use. The formulation as a nano-emulsion effectively overcomes this limitation. Stability of the nano-emulsion “There was an important idea and it was adapted in our laboratory,” R Nagarajan, professor in the department of chemical engineering at IIT-Madras, told PTI news agency.
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Animal studies have been successfully completed with planned clinical trials.
Researchers at IIT-Madras are currently working on the safety and cost issues which are major challenges in existing cancer drugs.
“We are looking at two to three years to bring the formulation to market,” said R Nagarajan.
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Animal validation (GLP phase) and efficacy studies (non-GLP phase) to adjust the dosage were carried out through the Pratiksha Trust with the funding support of Gopalakrishnan, distinguished alumnus awardee of IIT Madras and co-founder of Infosys. Is.
“Researchers at IIT Madras have patented the use of Indian spices for cancer treatment,” Gopalakrishnan wrote on the X platform.
M Joyce Nirmala, Chief Scientific Officer (Cancer Nanomedicine and Drug Design Laboratory), IIT Madras, said the patented Indian spice-based nano-formulation has been proven effective in several common types of cancer through in-vitro studies.
“This cancer nanomedicine is being developed to reduce the cost and pain of cancer treatment and to overcome the toxic side effects seen in existing cancer treatments,” Nirmala said.
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IIT Madras officials said that over the past two decades, nano-oncology has shown promise as an emerging strategy in cancer therapy, diagnosis and prevention, demonstrating positive results in research and clinical trials.
Chemotherapy has been used as a treatment strategy since the 1930s, with other common treatment options being radiotherapy and surgery. However, conventional treatment options are often associated with pain, toxic side effects, lack of targeting efficiency, and high costs.
“Since complete eradication of cancer is impossible through existing treatments, the role of nanomedicine is becoming more important,” Nirmala said.
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Published: 27 February 2024, 07:36 am IST
