A new study led by researchers at Oxford Population Health has shown that various types of environmental factors including lifestyle options (such as smoking and physical activity) and living conditions are more important on health and premature death than our genes. Effects.
The study, which analyzed the data of about half a million UK biobank participants, examined the effects of 164 environmental factors and genetic risk scores for 164 major diseases on aging, age -related diseases and premature diseases. The conclusions were published in Nature Medicine today.
According to major findings, environmental factors explained 17% of the variation in the risk of death, while compared to less than 2% explained by genetic trend (current).
Among the 25 independent environmental factors identified in the event of identity, smoking, socio -economic condition, physical activity and living conditions had the most impact on mortality and biological aging. Smoking was associated with 21 diseases; Socio Economic Factors, such as domestic income, domestic ownership and employment status, were associated with 19 diseases; And physical activity was associated with 17 diseases.
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Lifestyle habits in terms of birth
Early life exposure, which included maternal smoking around body weight and birth in 10 years, was shown to affect the risk and risk of premature death 30–80 years later.
Risk factor based on environmental risk
Environmental risks had a greater effect on lungs, heart and liver diseases, while genetic risk dominated for dementia and breast cancer.
“Our research shows the intensive health effects of exposure, which is the intensive health effects of the exposure, which is the intensive health effects of the exposure, which is to improve socio -economic conditions by individuals or by policies For, to reduce smoking, can reduce smoking, to reduce smoking, smoking, smoking To do, or promote physical activity.
Research suggests that when many different exposures identified a small part in premature death, the joint effects of these many exposure performed a time together on the life course (referred to as exposoms) simultaneously Before explained a large proportion of mortality variation. The insight to this study paves the way for integrated strategies to improve the health of the aging population by identifying the major combinations of environmental factors that paves the risk of premature death and many general age related diseases simultaneously Are.
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