Three scientists have jointly awarded the Nobel Prize in Physiology or Medicine for their leading discoveries related to the immune system. These findings have opened new avenues for research and development of cancer and autoimmune diseases.
At the Karolinska Institute in Stockholm, Nobel Assembly announced on Monday that Mary E. Branco, Fred Ramsdel, and Shimon Sakaguchi will share the 11 million-Kron ($ 1.2 million) prize.
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Mary e. Branko (US): She holds the position of Senior Program Manager at Institute for Systems Biology at Seattle, US. He and Fred Ramsdel were credited with a major discovery of FoxP3 genes, indicating that a mutation in this gene causes a serious autoimmune disease (IPEX) and is important for TREG cell function.
The Nobel Committee stated that the three scientists were identified for their groundbreaking discoveries “related to peripheral immune tolerance that prevents the immune system from damaging the body”.
He identified the security guards of the immune system, regulatory T cells, thus laying the foundation for a new area of ​​research “.
In a social media post on X, the official handle of the Nobel Prize said: “Mary Branch and Fred Ramsdel – who has been awarded the 2025 Nobel Prize in Physiology or Medicine – received decisive insight as autoimmune diseases. Disease.”
“The Medicine Larates found that mice contained a mutation in a gene that he has named Foxap 3. He also showed that mutation in the human counterpart of this gene causes a serious autoimmune disease, IPEX,” said this.
The committee has led the development of potential medical remedies, which are now being evaluated in clinical trials, the committee saw.
